![]() Methods: To explore the cost-effectiveness of Andexxa, a Markov model was generated using existing Andexxa trial data and related literature. Andexxa is costly, however, ranging between US $24,750 and $49,500 for treatment. It has been reported to substantially reduce mortality rates for patients who experience a major bleed while taking rivaroxaban or apixaban. In May 2018, the US Food and Drug Administration approved andexanet alfa (Andexxa), the first known reversal agent for a subset of direct factor Xa inhibitors. ![]() ![]() Introduction: Tens of thousands of patients die of major life-threatening bleeds every year while taking direct factor Xa inhibitors, a class of anticoagulant medications that until now had no reversal agent. ![]()
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